Silicon Nanochip Can Reprogram Living Tissues in the Body

Silicon Nanochip Can Reprogram Living Tissues in the Body

A silicon chip that can change skin tissue and turn it into vessels and nerve cells has gone from prototype stage to standard production stage. This means that the chip can now be produced continuously and repeatedly. The study, published in Nature Protocols by researchers from Indiana University School of Medicine, brings the device one step closer to using the device as a potential treatment for people with a variety of health conditions.

The technology, called tissue nanotransfection, is an interference-free nanochip device that can transfer certain genes in a few milliseconds by applying a harmless electric spark, thereby reprogramming tissue function. In laboratory studies, the device successfully transformed the skin tissue into veins, enabling the repair of a severely injured leg. The technology is currently in the reprogramming of tissues for different types of therapy; For example, it is used to repair brain damage caused by stroke, or to prevent or reverse damage to nerves caused by diabetes.

“This report on exactly how these tissue nanotransfection chips can be fabricated will enable other researchers to contribute to this new advancement in regenerative medicine,” said Chandan Sen, professor of medicine, chair of the Indiana University Center for Regenerative Medicine and Engineering, vice president of research, and lead author of the new study. .

Sen also leads the innovative medicine and engineering arm of the Indiana University Precision Health Initiative.

“This tiny silicon chip enables nanotechnology to change the function of living body parts,” he says. “For example, if someone’s veins have been damaged by a car accident and that person needs a new supply of blood, we can no longer rely on pre-existing veins because they have been crushed. But we can turn the skin tissue into veins and save the endangered limb.”

In the report published in Nature Protocols, the researchers share the engineering details of how the chip was fabricated.

Sen says this manufacturing knowledge will lead to further development of the chip and that the chip will perhaps one day be used in clinical settings in many parts of the world.

“It’s about engineering and manufacturing the chip,” he says. “The nano-fabrication process of the chip usually takes five or six days. With the help of this report, the chip can be produced by anyone who is an expert.”

Sen says he hopes to get FDA approval for the chip within a year. Once approved by the FDA, the device can be used in clinical trials in humans. Its uses include patients in hospitals, health centers and emergency rooms, as well as first responders or other emergencies faced by the military.

Source: Indiana University https://popsci.com.tr/

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