Mutations Identified in Delta and Delta+ Variants
Kamlendra Singh, a professor at the University of Missouri School of Veterinary Medicine and Bond Life Sciences Center, started coughing and had a fever on the plane, despite having a COVID-19 vaccine and a negative virus test just before boarding the plane, while coming to the USA from India in April.
The COVID-19 test Singh had when he arrived was positive, most likely due to contamination of the Delta variant. People who are fully vaccinated and those who have already tested positive for the contagious virus also experience this diagnosis. Singh wanted to know the reason for the situation.
After recovering at home, Singh teamed up with Austin Spratt, a graduate student at the University of Missouri, Saathvik Kannan, a freshman at Hickman High, and Siddappa Byrareddy, a professor at the University of Nebraska Medical Center, to identify new variants known as Delta and Delta+ in more than 300,000 COVID-19 samples. set to analyze its protein sequences.
Using bioinformatics tools and programming methods, the research team identified five specific mutations that were much more dominant in Delta+ infections than in Delta infections. Among these is a mutation called K417N, which is found in almost all Delta+ infections but not found in almost any Delta infection. The findings, which provide important clues to recent structural changes in the virus, highlight the need to expand the toolkit in the fight against COVID-19.
“Whether it is natural antibodies from having previously had COVID-19, or vaccine-produced antibodies; “We show how inherently dangerous the virus is, by apparently mutating in a way that antibodies don’t recognize and protect against these new variants,” says Spratt. “The findings may help explain why so many people test positive for the Delta variant despite having been vaccinated or previously infected with COVID-19.”
The findings were presented last week in the Journal of Autoimmunity.
Source: Columbia – University of Missouri https://popsci.com.tr/ Photo: SARS-CoV-2 virus particles as a transmission electron microscope image. Image: NIAID